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KMID : 1098420080160040273
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 4 p.273 ~ p.278
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Antiviral Activity of Zanthoxylum Species against Influenza Virus
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Choi Hwa-Jung
Song Jae-Hyoung
Kwon Dur-Han
Baek Seung-Hwa
Ahn Young-Joon
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Abstract
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We aimed to investigate the antiviral activity of Zanthoxylum species against influenza virus A/WS/33, A/PR/8 and B/Lee/40 used by sulforhodamine B (SRB) assay and the action of leaves extracts of Zanthoxylum piperitum on life cycle of influenza virus A/WS/33. Among the twelve extracts, only the leaf extract of Z. piperitum exhibited strong antiviral activity at low concentration of less than 10 with no citotoxicity (50) against all of three viruses. In addition, only oseltamivir showed antiviral activity with of 65.3 against influenza A/WS/33 among the viruses. Furthermore, the leaf extract of Z. piperitum suppressed infection of influenza virus A/WS/33, when added just prior (-1 hr) or after virus inoculation (0 hr). Leaf extract of Z. piperitum directly affect the infectivity of influenza virus A/WS/33 particles. Therefore, Leaf extract of Z. piperitum exhibited higher antiviral activity against three influenza viruses than that of the oseltamivir, which directly interacts with influenza A/WS/33 particles, affecting the initial stages of infection such as receptor binding and virus entry.
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KEYWORD
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Influenza virus, Zanthoxylum piperitum, Oseltamivir, Cytotoxicity, Antiviral activity
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